Silicone is soft and lifelike, it is hypoallergenic, warms up quickly to body temperature, non-porous and so is easy to clean (with mild soap and water, or boiled for sterilization). Unlike jelly rubber and other porous materials, silicone can be sterilized in temperatures up to 300 °C (572 °F). In addition, it can be bleached in a 10% bleach solution. When using lubricants with silicone sex toys it is important that silicone or silicone-based lubricants are not used to avoid damage to the toy.

CyberSkin is a thermal plastic elastomer and is a close emulation of real skin. CyberSkin is made from ingredients on FDA approved lists and it does not contain phthalates, polyvinyl chloride (PVC), heavy metals or latex. It is easy to clean and maintain by washing it with soap and water, patting dry. Water based lubricants are best and they should be stored in a dry place.

Latex rubber, also called jelly rubber, is commonly used for sex toys; it is a flexible and inexpensive material allowing the user more options in size and look. While latex is commonly used and less expensive than materials such as silicone, glass and CyberSkin, it can be allergenic to some people with latex allergy. Latex is porous and should be cleaned thoroughly with an antibacterial soap and water and not shared with other people. Some rubber toys contain phthalates which are used to soften rubber, but carry serious risks. Studies have been done that showed adverse reproductive effects in animal and human subjects. Further research is ongoing but phthalates have a known detrimental effect on multiple facets of human health and their use in sex toys is strongly discouraged. It is recommended by many experts that one use a condom with each use for protection against bacterial infection or sexually transmitted diseases if one is sharing sex toys. Water and silicone-based lubricants can be used with latex toys, but oil-based lubricants and petroleum jelly should not be used with latex as these may adversely affect the toy.